Benzo apyrene levels in food food concentration ngg meat fried or broiled beef 0. Benzo apyrene bap is the most potent carcinogenic substance among the pahs and as long as its relative contribution to total pah is relatively constant in foods, bap concentration is a good indicator of the total carcinogenic potency of a mixture alexander et al. Pdf benzo alpha pyrene bap is a prototype polycyclic aromatic hydrocarbon pah. Recently, an increasing number of human and animal studies have reported that exposure to benzoapyrene bap induces neurological abnormalities and is also associated with adverse effects, such as tumor formation, immunosuppression, teratogenicity, and hormonal disorders. Benzoapyrene is a polycyclic aromatic hydrocarbon and the result of incomplete combustion of organic matter at temperatures between 300 c 572 f and 600 c 1,112 f. Section ii provides information on three aspects of the carcinogenic assessment for the substance in question. Benzog,h,iperylene fact sheet us epa archive document. It is also found in emissions from combustion of oil, coal, wood and garbage. Benzo apyrene in urban environments of eastern moscow. It has also been used to make bile acids, cholesterol and steroids.
Benzo apyrene standard benzo apyrene standard with a purity of 99. Gcmsms analysis of benzoapyrene with agilent 7890 and 240. Manmade releases of benzoapyrene are to the air, where. Learn how californias climate is changing and how these changes are affecting the state. Benzoapyrene equivalents calculator multiple samples. There are few studies addressing the molecular and. This section provides information on three aspects of the carcinogenic risk assessment for. This structure is also available as a 2d mol file or as a computed 3d sd file the 3d structure may be viewed using java or. Formation and persistence of benzoapyrene metabolitedna. This iris assessment for benzoapyrene bap consists of hazard identification and doseresponse assessment data and provides support for epa risk management decisions. This structure is also available as a 2d mol file or as a computed 3d sd file.
Pollution levels and critical loads article pdf available in atmospheric chemistry and physics 173. Benzo a pyrene at human blood equivalent level induces human lung epithelial cell invasion and migration via aryl hydrocarbon receptor signaling. More benzoapyrene bap is a polycyclic aromatic hydrocarbon and a potent inducer of carcinogenesis. Pdf a multimedia transport model was used to evaluate the environmental partitioning of benzoapyrene bap. Incidence of nonneoplastic and neoplastic lesions in female b6c3f 1 mice fed benzo apyrene in the diet for up to 2 years d53 table d. Where can benzoapyrene be found and how is it used. Benzoapyrene is an important commercial chemical used to make dyes. Benzoapyrene bp and other polycyclic aromatic hydrocarbons pah are ubiquitous environmental pollutants and are suspected to be carcinogenic in man. Iris file for information on longterm toxic effects other than carcinogenicity. Please see the following for information about the library and its accompanying search program. Many studies have reported that the carcinogenic effects of bap might be due to its intermediate metabolites and to reactive. Benzoapyrene bap is one of a large number of polycyclic aromatic hydrocarbons pahs that are formed during the incomplete combustion of organic matter.
Neither the european commission nor any person acting on behalf of the commission. Most of the pahs with low vapour pressure in the air are adsorbed on particles. Gcmsms analysis of benzoapyrene with agilent 7890 and. Benzoapyrene was also reported in cooking oils, butter, fats, margarine, coffee, tea, and some cereals, fruits and vegetables. Substance name benzog,h, iperylene casrn 191242 last revised 12011990. Sum of carcinogen pahs chrysene, benzo apyrene, benzo b fluoranthene, benzokfluoranthene and dibenzo a,hanthracene ranged between 1. Less benzoapyrene bap is a polycyclic aromatic hydrocarbon and a potent inducer of carcinogenesis. The florida department of environmental protection is the states lead agency for environmental management and stewardship protecting our air, water and land. They are formed during the combustion of carbonaceous material at high temperatures 1. Evidence pertaining to the male reproductive toxicity of benzoapyrene in adult animals after oral or inhalation. The in vivo formation of bp metabolitedna adducts has been characterized in a variety of target. Pyrene is an ortho and perifused polycyclic arene consisting of four fused benzene rings, resulting in a flat aromatic system. Jul 01, 2014 information on benzo apyrene bap, an indicator species for polycyclic aromatic hydrocarbons pahs, for use in responding to chemical incidents.
Information on benzo apyrene bap, an indicator species for polycyclic aromatic hydrocarbons pahs, for use in responding to chemical incidents. The ubiquitous compound can be found in coal tar, tobacco smoke and many foods, especially grilled meats. Concentrations of benzo apyrene in benzo apyrene benzo apyrene was considered by previous iarc working groups in 1972, 1983, and 2005 iarc, 1973, 1983, 2010. Material safety data sheet toxin and toxintarget database. Like most pahs, benzo g,h,iperylene is used to make dyes, plastics, pesticides, explosives and drugs. Expl ther a 1% soln of benzoapyrene in benzene was applied daily to protected and unprotected surfaces of skin of 26 patients suffering from pemphigus vulgaris, mycosis fungoides, prokeratosis, xeroderma pigmentosum, basal cell cancer, squamous cell cancer, lupus erythematosis, psoriasis, syphilis in various stages, or ringworm. Pdf benzo a pyrene at human blood equivalent level. Bap is a polycyclic aromatic hydrocarbon and a component of air pollution. All mass spectra in this site plus many more are available from the nistepanih mass spectral library. Industries where occupational exposure to benzoapyrene has been measured and reported. Oxidized by ozone, chromic acid and chlorinating agents. Calculators benzoapyrene equivalents calculator multiple samples about dep. However, the exact mechanisms underlying bapinduced.
Benzo apyrene is on the priority pollutant list published by the u. Jrcirmm catalogue pdf format or jrcirmm catalogue search engine. Information from its description page there is shown below. Benzoapyrene, or bap, is one of a group of compounds called polycyclic aromatic hydrocarbons pahs. Benzo apyrene is found in nature from the eruption of volcanoes and forest fires. Benzoapyrene is found in nature from the eruption of volcanoes and forest fires. Where can benzo apyrene be found and how is it used. Here, we show that exposure of human cells to benzo apyrene 9,10diol7,8epoxide bpde, the active metabolite of benzo apyrene bap, which represents a most important carcinogen formed during food preparation at high temperature, smoking and by incomplete combustion processes, causes a prompt and sustained upregulation of the dna repair. They are not produced or used commercially but are very commonly found since they are formed as a result of incomplete combustion. Benzoapyrene c20h12 cid 2336 structure, chemical names, physical and chemical properties.
Media in category benzoapyrene the following 22 files are in this category, out of 22 total. They have a relatively low solubility in water, but are highly lipophilic. Determination of benzoapyrene levels in smoked and oil. Polycyclic aromatic hydrocarbons benzoapyrene toxicological. Benzoapyrene is part of a class of chemicals called polycyclic aromatic hydrocarbons. Benzoapyrene undergoes photooxidation after irradiation in indoor sunlight or by fluorescent light in organic solvents.
Benzo a pyrene equivalents conversion table for multiple. Pyrene is a parent class of polycyclic aromatic hydrocarbons containing four fused rings. Pyrene is a colorless solid, solid and solutions have a slight blue fluorescence. Since that time new data have become available, which have been. Instructions for benzo apyrene mcl notice tier 2 violation since exceeding the benzo apyrene maximum contaminant level mcl is a tier 2 violation, you must provide public notice to persons served as soon as practical but within 30 days after you learn of the violation 40 cfr 141. Relevant identified uses of the substance or mixture and uses advised against identified uses laboratory reagent. Tobacco smoke contains high concentrations of pahs iarc, 2010. Benzoapyrene chemical agents and related occupations. Sample application of adafs for the estimation of benzo apyrene cancer risk.
Benzo apyrene page 3 of toxicological overview introduction pahs are a large group of compounds consisting of hydrocarbons containing two or more benzene rings fused together or to other hydrocarbon rings. The absorption of benzo apyrene from the gastrointestinal tract of mice and cats is enhanced when it is solubilized in vehicles possessing both lipophilic and hydrophilic properties ekwall et al. Less benzo apyrene bap is an environmental contaminant produced during incomplete combustion of organic. Product name benzo apyrene product number fb18224 synonyms. Adaptive upregulation of dna repair genes following benzoa. Once benzo apyrene has entered the small intestine, it is solubilized by bile salts and absorbed ermala et al. Incompatible with strong oxidizing agents including various electrophiles, peroxides, nitrogen oxides and sulfur oxides. Polycyclic aromatic hydrocarbons pahs european commission.
At the june 1992 crave work group meeting, a revised risk estimate for benzo apyrene was verified see additional comments for oral exposure. Benzoapyrene is on the priority pollutant list published by the u. More benzo apyrene bap is an environmental contaminant produced during incomplete combustion of organic material that is well known as a mutagenic and carcinogenic toxin. Benzo a pyrene equivalents conversion table for multiple samples home divisions division of waste management petroleum restoration program benzo a pyrene equivalents conversion table for multiple samples. Benzoapyrene bap is the most potent carcinogenic substance among the pahs, and as long as its relative contribution to total pah is relatively constant in foods, bap concentration is a good indicator of the total carcinogenic potency of a pah mixture alexander et al. Gcmsms analysis of benzoapyrene with agilent 7890 and 240 june 17, 2011 confidentiality label 1 linearity and precision eimsms.
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